Yesterday (2020-1-15), the American Medical Association journal JAMA published the Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands.

I think most people know that vitamin B12 is important for health, but most people don’t know that excessive vitamin B12 is dangerous. I published "Vegetarian, take B12 from seaweed?" 》, vegetarians should not listen to the suggestion of a so-called fertility expert to take Vitamin B12 from seaweed. At the end of this article I have provided a research paper published just a month ago that shows that excessive vitamin B12 can increase the risk of fractures. See Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses’ Health Study (In the Nurses Health Study, high intakes of vitamin B6 and B12 in food and supplements of women with postmenopausal women is related to the risk of lateral fractures).

In addition to increasing fracture risk, too many vitamin B12 is also positively related to mortality. Please see the following three research papers:

Elevated Total Homocysteine ​​in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study (All participants’ total homocysteine ​​levels and concentrations of female blood vitamin B12 are related to very old all-cause and cardiovascular mortality: Newcastle 85+ study)

Elevated Plasma Vitamin B12 Concentrations Are Independent Predictors of In-Hospital Mortality in Adult Patients at Nutritional Risk

Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients (the relationship between serum vitamin B12 and leaf acid and mortality in hemodialysis patients)

The above three papers are all studies of special ethnic groups (high-age, kidney washing, hospitalization). However, this article published in the American Medical Association journal yesterday is for ordinary people, so it should be worthy of everyone's attention. There were 40,856 people in the first place in the study, but after a series of screenings, only 5,571 people were qualified (about half men and half each, with an average of 53.5 years old). They are assigned into four groups according to the blood concentration of vitamin B12. The first group has a vitamin B12 concentration of less than 338.85pg/ml, and the fourth group is greater than 455.41pg/ml. After more than eight years of tracking and removing all possible interference factors (such as age, gender, obesity, kidney function, etc.), the analysis found that the mortality rate in the fourth group was about twice that in the first group.

In view of this, the research report finally provides such suggestions:

There are too much entry into vitamin B12, especially vitamin B12, which has attracted attention. A study report conducted by Løland et al. in 2010 reported that supplementing vitamin B has no beneficial effects on the progression of crown-state disease, as previously assumed. In addition, in a prospective study of 75,864 women, vitamin B12 supplementation was associated with an increased risk of facial fractures. From this meaning, our results may also suggest that we should act cautiously on whether to supplement Vitamin B12 without the lack of Vitamin B12.

Original text: The higher the concentration of vitamin B12, the higher the mortality rate